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Image Search Results
Journal: Molecular Medicine Reports
Article Title: Effects of combined treatment with PD-L1 Ig and CD40L mAb on immune tolerance in the CBA/J × DBA/2 mouse model
doi: 10.3892/mmr.2020.10977
Figure Lengend Snippet: Expansion of the CD4 + CD25 + T-cell population is driven by combined treatment with PD-L1 Ig and anti-CD40L mAbs in the CBA/J × DBA/2 model. (A) Number of CD4 + CD25 + T cells in splenocytes was determined by flow cytometry. (B) Gating strategy used for flow cytometry, using the FSC/SSC method. R1 represents the T lymphocyte population. (C) Percentage of CD4 + CD25 + T cells. ***P<0.001 vs. the normal group (CBA/J × BALB/c). ### P<0.001 vs. the spontaneous abortion group (CBA/J × DBA/2); &&& P<0.001 vs. PD-L1 Ig + CD40L mAb group. PD-L1, programmed death-ligand 1; Ig, immunoglobulin; CD40L, CD40 ligand; mAb, monoclonal antibody; FSC, forward scatter; SSC, side scatter; PE, phycoerythrin.
Article Snippet: The splenic cells were labeled with both
Techniques: Flow Cytometry